The blaze, which quickly went to three alarms, erupted at 65-55 Maurice Ave., near 51st Avenue, just before 7:50 p.m.
It quickly consumed the home and spread to two adjoining buildings.
Nearly 140 firefighters raced to the scene and battled the blaze for more than three hours.
All of the residents of the house were able to make it out of the house, officials said.
Three firefighters suffered minor injuries.
The cause was under investigation.